BENIGN FAMILIAL NEONATAL
BENIGN FAMILIAL NEONATAL SEIZURES.
They are BENIGN that is the outcome epileptic as well as neurological is
NORMAL. Normal future neurodevelopment and no secondary epilepsy. Immediately
there is a problem: what about children who had benign neonatal
seizures and at 8 develop Rolandic spikes? But let's continue on.
To determine the benign aspect of NNS one must take into account:
Critical and Intercritical
-mono vs. polytherapy
Since initial description in 1964, there has been 144 cases
usually 2nd or 3rd day but as late as 3rd month.
are either clonic or tonico-clonic or apneic. Rarely tonic. Uni or
bilateral sometimes alternating. Short lasting less than 1 to 3 mn they
are isolated and can be repeated over next weeks.
seizures the child is normal.
particular anomaly described in the Intercritical state. Theta pointu
alternant can be seen. Critical discharges have no particular characteristic: short uni or bilateral discharges.
-Evolution is benign and the neurological
outcome is normal. But there has been children who developed further
seizures. They have always been easy to control.
Male = female
Autosomal dominant transmission
Anomaly on long arm of chromosome 20, exactly on q13.2