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DRUG INFORMATION

   

TREATMENT's PRINCIPLES

 

1. Diagnostic:

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 It is primordial to have a precise diagnosis for the type of SEIZURES and the type of EPILEPSY.

 There is usually no urgency to start an AED. It is preferable to take the time for a good history, a good physical and a good set of investigations including EEG, preferably with sleep EEG.

 For example it is easy to diagnose a West syndrome, but it is much better to distinguish a cryptogenic one from a symptomatic one. Treatment and prognosis may well be different.

Similarly, a child may well present with what appears to be absences. But if the EEG does not show any generalized, regular 3 c/s SW, it may be complex partial seizures which will respond better to Tegretol.

 2. Monotherapy:

 We will always look for the best adapted AED, with the least side effects. Monotherapy will be efficacious in 50% of cases, a change in AED will bring this control rate to 66 %. In the remaining 25% a polytherapy will have to be initiated. 75% of patients are controlled with one or 2 AED's, multiple AED's therapy brings this number up to about 80%. In 20% of cases, the seizures are refractory to treatment. In these children the Ketogenic diet has brought lots of help.

3. When to treat?

 The choice is either:

                       -Do nothing

                        -Treat the aetiology

                        -Treat the seizures.

One has to weight the benefice vs the side effects: long term treatment, label of chronic disorder, side effects of AED.

In children one also needs to take into account 1: the pharmacocinetic (absorption, distribution, elimination) 2: the taste of the medication 3: the presentation. eg: think twice before prescribing VPA to an obese child.

 

4. Follow-up.

 Must be clinical, biological controls, pharmacological control,and EEG.

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5. When to stop?

 2 to 3 years seizure-free. Relapse rate depends on type of epilepsy, type of seizures, age of onset, duration of seizures, EEG.

 

6. What medication?

There are several medications that can be used. Traditionally the choice of anticonvulsant was as follows:

PRIMARY GENERALIZED

Tonic-clonic:    V P A, C B Z, P H T

Absences:        V P A, E S M

Infantile Spasms: C Z P

Myoclonic: V P A, C Z P

LOCALIZATION RELATED

Simple Partial Seizures: C B Z, P H T, V P A

Complex Partial Seizures: C B Z, P H T, V P A

Secondary Generalized: C B Z, P H T, V P A

VPA: Valproic Acid

CBZ: Carbamazepine

PHT: Phenytoin

ESM: Ethosuccimide

CZP: Clonazepam

More recently it has appeared that most of the AED's have the same efficacy as first intention (in the appropriate cases of course).